Acta Pædiatrica (Maria Petersson) – 28/2/12 9:21 μ.μ.


Aim:  The relationship between depression in adolescents and vitamin D was studied in a case-series which included effects of vitamin D supplementation.

Methods:  Serum 25OH vitamin D (25OHD) levels in 54 Swedish depressed adolescents were investigated. Subjects with vitamin D deficiency were given vitamin D3 over three months (n=48).

To evaluate well-being and symptoms related to depression and vitamin D status the WHO-5 well-being scale, The Mood and Feelings Questionnaire (MFQ-S), and a vitamin D deficiency scale were used.

Results:  Mean serum 25OHD in the depressed adolescents was 41 at baseline and 91 nmol/L (p<0.001) after supplementation. Basal 25OHD levels correlated positively to well-being (p<0.05). After vitamin D supplementation well-being increased (p<0.001) and there was a significant improvement in seven of the nine items in the vitamin D deficiency scale; in depressed feeling (p<0.001), irritability (p<0.05), (p<0.001), tiredness (p<0.001), mood swings (p<0.01), sleep difficulties (p<0.01), weakness (p<0.05), ability to concentrate (p<0.05) and pain (p<0.05). There was a significant amelioration of depression according to the MFQ-S (p<0.05) Conclusion:  This study showed low levels of vitamin D in 54 depressed adolescents, positive correlation between vitamin D and well-being, and improved symptoms related to depression and vitamin D deficiency after vitamin D supplementation. © 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica

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